The relationship between inflammatory dietary pattern in childhood and depression in early adulthood

Inflammation may be a hidden process in the relationship between dietary intake and depression, but no study has evaluated the role of diet and inflammation jointly in explaining depression risk in early life. The current study aims to investigate the relationship between inflammatory dietary patter...

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Bibliographic Details
Published in:Brain, behavior, & immunity. Health behavior, & immunity. Health, 2020-02, Vol.2, p.100017-100017, Article 100017
Main Authors: Cong, Xiao, Tracy, Melissa, Edmunds, Lynn S., Hosler, Akiko S., Appleton, Allison A.
Format: Article
Language:English
Subjects:
ALSPAC
C-reactive protein
Children
Cohort
Depression
Full Length
Inflammatory biomarkers
Inflammatory dietary pattern
Interleukin-6
Reduced rank regression
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Summary:Inflammation may be a hidden process in the relationship between dietary intake and depression, but no study has evaluated the role of diet and inflammation jointly in explaining depression risk in early life. The current study aims to investigate the relationship between inflammatory dietary pattern (IDP) in childhood and depression in early adulthood. This study used data prospectively collected over 10 years from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort (n ​= ​6939) free from depression at baseline (age 8.5 years). An IDP score was empirically derived via reduced rank regression and stepwise linear regression based on dietary intake data from the food frequency questionnaire at 8.5 years and levels of inflammatory biomarkers, C-reactive protein and interleukin-6, at 9.5 years. At age 18 years, depression cases were identified via the International Statistical Classification of Diseases, 10th Revision (ICD-10) diagnosis and the Clinical Interview Schedule-Revised (CIS-R) depression score. Logistic regression models were constructed to examine the relationship between the IDP score and risk of depression adjusted for potential confounders. Analyses stratified by weight status were also conducted. Multiple imputations were utilized to minimize bias due to loss-to-follow-up. Participants in the highest tertile of IDP score had 1.34 times odds to develop depression compared to those in the lowest tertile (95% CI, 1.08–1.66; P-trend
ISSN:2666-3546
2666-3546
DOI:10.1016/j.bbih.2019.100017