Gut mycobiome alterations and implications for liver diseases

Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfuncti...

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Bibliographic Details
Published in:PLoS pathogens 2024-08, Vol.20 (8), p.e1012377
Main Authors: Zeng, Suling, Schnabl, Bernd
Format: Article
Language:English
Subjects:
Analysis
Animals
Antifungal agents
Biology and Life Sciences
Care and treatment
Composition
Diagnosis
Dosage and administration
Dysbiosis - microbiology
Fungi - pathogenicity
Gastrointestinal Microbiome - physiology
Humans
Liver diseases
Liver Diseases - microbiology
Medicine and Health Sciences
Microbiota (Symbiotic organisms)
Mycobiome
Review
Risk factors
RNA sequencing
Citations: Items that this one cites
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Summary:Chronic liver disease and its complications are a significant global health burden. Changes in fungal communities (mycobiome), an integral component of the gut microbiome, are associated with and contribute to the development of liver disease. Fungal dysbiosis can induce intestinal barrier dysfunction and allow fungal products to translocate to the liver causing progression of disease. This review explores recent progress in understanding the compositional and functional diversity of gut mycobiome signatures across different liver diseases. It delves into causative connections between gut fungi and liver diseases. We emphasize the significance of fungal translocation, with a particular focus on fungal-derived metabolites and immune cells induced by fungi, as key contributors to liver disease. Furthermore, we review the potential impact of the intrahepatic mycobiome on the progression of liver diseases.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1012377