Astragaloside IV: An Effective Drug for the Treatment of Cardiovascular Diseases

• Published in: Drug design, development and therapy development and therapy, 2020-01, Vol.14, p.3731-3746
• Main Authors: Tan, Yu-Qing, Chen, Heng-Wen, Li, Jun
• Format: Article
• Language: English
• Subjects: Adenosine triphosphate; Angiogenesis; Anticancer properties; Apoptosis; astragaloside iv; Astragalus membranaceus; Astragalus propinquus - chemistry; Bioavailability; Blood; Blood glucose; Cardiac function; Cardiomyocytes; Cardiovascular diseases; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - pathology; Cell injury; Chinese medicine; Disease prevention; Drug development; Drug therapy; Drugs; Drugs, Chinese Herbal - chemistry; Drugs, Chinese Herbal - therapeutic use; Fibrosis; Gene expression; Glucose; Health risks; Health services; Heart; Heart diseases; Herbal medicine; Humans; Hypertrophy; Hypoxia; Ischemia; Kinases; Lipids; Medical treatment; Medicinal plants; Medicine, Chinese Traditional; Metabolism; Mitochondria; Mode of action; Molecular Conformation; Muscle contraction; Natural products; Pharmacokinetics; Proteins; Review; Saponins - chemistry; Saponins - therapeutic use; Side effects; Traditional Chinese medicine; Triterpenes - chemistry; Triterpenes - therapeutic use; Veins & arteries
• ISSN: 1177-8881; 1177-8881
• DOI: 10.2147/DDDT.S272355

Cardiovascular disease (CVD), the number one cause of death worldwide, has always been the focus of clinical and scientific research. Due to the high number of deaths each year, it is essential to find alternative therapies that are safe and effective with minimal side effects. Traditional Chinese medicine (TCM) has a long history of significant impact on the treatment of CVDs. The mode of action of natural active ingredients of drugs and the development of new drugs are currently hot topics in research on TCM. is a commonly used Chinese medicinal herb. Previous studies have shown that has anti-tumor properties and can regulate metabolism, enhance immunity, and strengthen the heart. Astragaloside IV (AS-IV) is the active ingredient of , which has a prominent role in cardiovascular diseases. AS-IV can protect against ischemic and hypoxic myocardial cell injury, inhibit myocardial hypertrophy and myocardial fibrosis, enhance myocardial contractility, improve diastolic dysfunction, alleviate vascular endothelial dysfunction, and promote angiogenesis. It can also regulate blood glucose and blood lipid levels and reduce the risk of cardiovascular diseases. In this paper, the mechanism of AS-IV intervention in cardiovascular diseases in recent years is reviewed in order to provide a reference for future research and new drug development.