Briarane diterpenoids from the gorgonian Dichotella gemmacea

Seven new briarane diterpenoids, gemmacolides AS-AY (1-7), were isolated together with ten known analogues (8-17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported da...

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Bibliographic Details
Published in:Marine drugs 2014-12, Vol.12 (12), p.6178-6189
Main Authors: La, Ming-Ping, Li, Jiao, Li, Cui, Tang, Hua, Liu, Bao-Shu, Sun, Peng, Zhuang, Chun-Lin, Li, Tie-Jun, Zhang, Wen
Format: Article
Language:English
Subjects:
Animals
Anthozoa - chemistry
briarane diterpenoids
Cell Line, Tumor
China
Dichotella gemmacea
Diterpenes - chemistry
Diterpenes - pharmacology
Gorgonacea
gorgonian
Humans
Marine
Spectrum Analysis
structure elucidation
tumor cell growth inhibitory activity
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Summary:Seven new briarane diterpenoids, gemmacolides AS-AY (1-7), were isolated together with ten known analogues (8-17) from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data and comparison with reported data. The absolute configuration of compounds was determined based on electronic circular dichroism (ECD) experiments and genetic correlations as well. Compounds 15 and 16 were reported for the first time for the gorgonian. In the preliminary in vitro bioassays, compound 5 showed potential growth inhibitory activity against MG63 cells.
ISSN:1660-3397
1660-3397
DOI:10.3390/md12126178