Handheld versus mounted laser speckle contrast perfusion imaging demonstrated in psoriasis lesions

Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline i...

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Bibliographic Details
Published in:Scientific reports 2021-08, Vol.11 (1), p.16646-16646, Article 16646
Main Authors: Chizari, Ata, Schaap, Mirjam J., Knop, Tom, Boink, Yoeri E., Seyger, Marieke M. B., Steenbergen, Wiendelt
Format: Article
Language:English
Subjects:
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Cameras
Correlation coefficient
Humanities and Social Sciences
Lasers
Light
Medical research
multidisciplinary
Patients
Perfusion
Psoriasis
Science
Science (multidisciplinary)
Segmentation
Skin
Skin diseases
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Summary:Enabling handheld perfusion imaging would drastically improve the feasibility of perfusion imaging in clinical practice. Therefore, we examine the performance of handheld laser speckle contrast imaging (LSCI) measurements compared to mounted measurements, demonstrated in psoriatic skin. A pipeline is introduced to process, analyze and compare data of 11 measurement pairs (mounted-handheld LSCI modes) operated on 5 patients and various skin locations. The on-surface speeds (i.e. speed of light beam movements on the surface) are quantified employing mean separation (MS) segmentation and enhanced correlation coefficient maximization (ECC). The average on-surface speeds are found to be 8.5 times greater in handheld mode compared to mounted mode. Frame alignment sharpens temporally averaged perfusion maps, especially in the handheld case. The results show that after proper post-processing, the handheld measurements are in agreement with the corresponding mounted measurements on a visual basis. The absolute movement-induced difference between mounted-handheld pairs after the background correction is 16.4 ± 9.3 % (mean ± std, n = 11 ), with an absolute median difference of 23.8 % . Realization of handheld LSCI facilitates measurements on a wide range of skin areas bringing more convenience for both patients and medical staff.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-96218-6