Dynamics of macrophage populations of the liver after subtotal hepatectomy in rats

In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size'...

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Bibliographic Details
Published in:BMC immunology 2018-07, Vol.19 (1), p.23-23, Article 23
Main Authors: Elchaninov, Andrey V, Fatkhudinov, Timur Kh, Usman, Natalia Y, Kananykhina, Evgeniya Y, Arutyunyan, Irina V, Makarov, Andrey V, Lokhonina, Anastasia V, Eremina, Irina Z, Surovtsev, Viktor V, Goldshtein, Dmitry V, Bolshakova, Galina B, Glinkina, Valeria V, Sukhikh, Gennady T
Format: Article
Language:English
Subjects:
Animals
Antibodies
Bone marrow
CD11b antigen
Gene expression
Hepatectomy
Homeostasis
Kupffer cells
Laboratories
Liver
Liver diseases
Macrophages
Malignancy
Morphology
Phenotypes
Proteins
Regeneration
Software
Surgery
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Summary:In many clinical cases of extensive liver resection (e.g. due to malignancy), the residual portion is too small to maintain the body homeostasis. The resulting acute liver failure is associated with the compensatory growth inhibition, which is a typical manifestation of the 'small for size' liver syndrome. The study investigates possible causes of the delayed onset of hepatocyte proliferation after subtotal hepatectomy (80% liver resection) in rats. The data indicate that the growth inhibition correlates with delayed upregulation of the Tnf gene expression and low content of the corresponding Tnfα protein within the residual hepatic tissue. Considering the involvement of Tnf/Tnfα, the observed growth inhibition may be related to particular properties of liver macrophages - the resident Kupffer cells with CD68 CX1CR3 CD11b phenotype. The delayed onset of hepatocyte proliferation correlates with low levels of Tnfα in the residual hepatic tissue. The observed growth inhibition possibly reflects specific composition of macrophage population of the liver. It is entirely composed of embryonically-derived Kupffer cells, which express the 'proregeneratory' M2 macrophage-specific marker CD206 in the course of regeneration.
ISSN:1471-2172
1471-2172
DOI:10.1186/s12865-018-0260-1