Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?

Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was...

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Published in:Journal of functional biomaterials 2023-03, Vol.14 (3), p.173
Main Authors: Ranković, Maja, Jevremović, Anka, Janošević Ležaić, Aleksandra, Arsenijević, Aleksandar, Rupar, Jelena, Dobričić, Vladimir, Nedić Vasiljević, Bojana, Gavrilov, Nemanja, Bajuk-Bogdanović, Danica, Milojević-Rakić, Maja
Format: Article
Language:English
Subjects:
Acridine
acridine derivatives
Adsorption
anticancer
Anticancer properties
Antitumor agents
Cancer
Care and treatment
Cell viability
Colorectal cancer
Colorectal carcinoma
Colorimetry
Crystal structure
Cytotoxicity
Drug delivery systems
Drug dosages
drug release
Electron microscopy
Fibroblasts
Investigations
Morphology
Physiology
Raman spectroscopy
Solvation
Surfactants
Toxicity
zeolite
Zeolites
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Summary:Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18-21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.
ISSN:2079-4983
2079-4983
DOI:10.3390/jfb14030173