Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model

In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (5), p.2647
Main Authors: Seo, Yong-Ho, Hwang, Su-Hyun, Kim, Yu-Na, Kim, Hyung-Joon, Bae, Eun-Bin, Huh, Jung-Bo
Format: Article
Language:English
Subjects:
Animals
Bone growth
Bone Regeneration
bone scaffold
Bones
Calvaria
Cancellous Bone
Cortical bone
Cranium
Defects
porcine
Porosity
Rabbits
Regeneration
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Skull
Surgery
Swine
Tissue Scaffolds
xenograft
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Summary:In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms23052647