Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model

In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2022-02, Vol.23 (5), p.2647
Main Authors: Seo, Yong-Ho, Hwang, Su-Hyun, Kim, Yu-Na, Kim, Hyung-Joon, Bae, Eun-Bin, Huh, Jung-Bo
Format: Article
Language:English
Subjects:
Animals
Bone growth
Bone Regeneration
bone scaffold
Bones
Calvaria
Cancellous Bone
Cortical bone
Cranium
Defects
porcine
Porosity
Rabbits
Regeneration
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Skull
Surgery
Swine
Tissue Scaffolds
xenograft
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33
cites cdi_FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33
container_end_page
container_issue 5
container_start_page 2647
container_title International journal of molecular sciences
container_volume 23
creator Seo, Yong-Ho
Hwang, Su-Hyun
Kim, Yu-Na
Kim, Hyung-Joon
Bae, Eun-Bin
Huh, Jung-Bo
description In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.
doi_str_mv 10.3390/ijms23052647
format article
fullrecord <record><control><sourceid>proquest_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_17d880089ba8472b9bc529506aadcfec</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_17d880089ba8472b9bc529506aadcfec</doaj_id><sourcerecordid>2638712739</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33</originalsourceid><addsrcrecordid>eNpdkk2P0zAQhiMEYj_gxhlZ4sJhA_5I4viCBF0-VioCLeVsTexJcZXaXTsp2j_Bb8Ztl1WXk0czz7zjGb1F8YLRN0Io-tat1okLWvOmko-KU1ZxXlLayMdH8UlxltKKUi54rZ4WJyLTSip2Wvz5EDySazTBpzFOZnTBk5_J-SVZ_A7lHG4xku8hGuexvMTotmjJvueHgb4PgyWzsN6ElNOhz3EcnYGBgM8F8AaHIUxp35GI8wTINXSdG3Nx2EJ0Gb3EHs1IvgaLw7PiSQ9Dwud373mx-PRxMftSzr99vpq9n5emku1YohSUMyVM1dWUCgHSKM4MZ2ihEkJ0ylrTN1AjtVwKi5zyBntTUclpJ8R5cXWQtQFWehPdGuKtDuD0PhHiUsNukQE1k7ZtKW1VB20leac6U3NV0wYgj0CTtd4dtDZTt0Zr0I8RhgeiDyve_dLLsNWtYrRuZBZ4fScQw82EadRrl3aHA4_5dpo3opUsr6Ey-uo_dBWm6POldpSUVVXVPFMXB8rEkFLE_v4zjOqdZ_SxZzL-8niBe_ifScRftCG-EA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2637744452</pqid></control><display><type>article</type><title>Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model</title><source>Publicly Available Content Database</source><source>PubMed Central(OpenAccess)</source><creator>Seo, Yong-Ho ; Hwang, Su-Hyun ; Kim, Yu-Na ; Kim, Hyung-Joon ; Bae, Eun-Bin ; Huh, Jung-Bo</creator><creatorcontrib>Seo, Yong-Ho ; Hwang, Su-Hyun ; Kim, Yu-Na ; Kim, Hyung-Joon ; Bae, Eun-Bin ; Huh, Jung-Bo</creatorcontrib><description>In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23052647</identifier><identifier>PMID: 35269791</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Bone growth ; Bone Regeneration ; bone scaffold ; Bones ; Calvaria ; Cancellous Bone ; Cortical bone ; Cranium ; Defects ; porcine ; Porosity ; Rabbits ; Regeneration ; Regeneration (physiology) ; Scaffolds ; Skin &amp; tissue grafts ; Skull ; Surgery ; Swine ; Tissue Scaffolds ; xenograft</subject><ispartof>International journal of molecular sciences, 2022-02, Vol.23 (5), p.2647</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33</citedby><cites>FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33</cites><orcidid>0000-0002-9524-3835 ; 0000-0002-2962-9553</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2637744452/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2637744452?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35269791$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Yong-Ho</creatorcontrib><creatorcontrib>Hwang, Su-Hyun</creatorcontrib><creatorcontrib>Kim, Yu-Na</creatorcontrib><creatorcontrib>Kim, Hyung-Joon</creatorcontrib><creatorcontrib>Bae, Eun-Bin</creatorcontrib><creatorcontrib>Huh, Jung-Bo</creatorcontrib><title>Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.</description><subject>Animals</subject><subject>Bone growth</subject><subject>Bone Regeneration</subject><subject>bone scaffold</subject><subject>Bones</subject><subject>Calvaria</subject><subject>Cancellous Bone</subject><subject>Cortical bone</subject><subject>Cranium</subject><subject>Defects</subject><subject>porcine</subject><subject>Porosity</subject><subject>Rabbits</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Scaffolds</subject><subject>Skin &amp; tissue grafts</subject><subject>Skull</subject><subject>Surgery</subject><subject>Swine</subject><subject>Tissue Scaffolds</subject><subject>xenograft</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk2P0zAQhiMEYj_gxhlZ4sJhA_5I4viCBF0-VioCLeVsTexJcZXaXTsp2j_Bb8Ztl1WXk0czz7zjGb1F8YLRN0Io-tat1okLWvOmko-KU1ZxXlLayMdH8UlxltKKUi54rZ4WJyLTSip2Wvz5EDySazTBpzFOZnTBk5_J-SVZ_A7lHG4xku8hGuexvMTotmjJvueHgb4PgyWzsN6ElNOhz3EcnYGBgM8F8AaHIUxp35GI8wTINXSdG3Nx2EJ0Gb3EHs1IvgaLw7PiSQ9Dwud373mx-PRxMftSzr99vpq9n5emku1YohSUMyVM1dWUCgHSKM4MZ2ihEkJ0ylrTN1AjtVwKi5zyBntTUclpJ8R5cXWQtQFWehPdGuKtDuD0PhHiUsNukQE1k7ZtKW1VB20leac6U3NV0wYgj0CTtd4dtDZTt0Zr0I8RhgeiDyve_dLLsNWtYrRuZBZ4fScQw82EadRrl3aHA4_5dpo3opUsr6Ey-uo_dBWm6POldpSUVVXVPFMXB8rEkFLE_v4zjOqdZ_SxZzL-8niBe_ifScRftCG-EA</recordid><startdate>20220228</startdate><enddate>20220228</enddate><creator>Seo, Yong-Ho</creator><creator>Hwang, Su-Hyun</creator><creator>Kim, Yu-Na</creator><creator>Kim, Hyung-Joon</creator><creator>Bae, Eun-Bin</creator><creator>Huh, Jung-Bo</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9524-3835</orcidid><orcidid>https://orcid.org/0000-0002-2962-9553</orcidid></search><sort><creationdate>20220228</creationdate><title>Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model</title><author>Seo, Yong-Ho ; Hwang, Su-Hyun ; Kim, Yu-Na ; Kim, Hyung-Joon ; Bae, Eun-Bin ; Huh, Jung-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Animals</topic><topic>Bone growth</topic><topic>Bone Regeneration</topic><topic>bone scaffold</topic><topic>Bones</topic><topic>Calvaria</topic><topic>Cancellous Bone</topic><topic>Cortical bone</topic><topic>Cranium</topic><topic>Defects</topic><topic>porcine</topic><topic>Porosity</topic><topic>Rabbits</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Scaffolds</topic><topic>Skin &amp; tissue grafts</topic><topic>Skull</topic><topic>Surgery</topic><topic>Swine</topic><topic>Tissue Scaffolds</topic><topic>xenograft</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Yong-Ho</creatorcontrib><creatorcontrib>Hwang, Su-Hyun</creatorcontrib><creatorcontrib>Kim, Yu-Na</creatorcontrib><creatorcontrib>Kim, Hyung-Joon</creatorcontrib><creatorcontrib>Bae, Eun-Bin</creatorcontrib><creatorcontrib>Huh, Jung-Bo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Yong-Ho</au><au>Hwang, Su-Hyun</au><au>Kim, Yu-Na</au><au>Kim, Hyung-Joon</au><au>Bae, Eun-Bin</au><au>Huh, Jung-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-02-28</date><risdate>2022</risdate><volume>23</volume><issue>5</issue><spage>2647</spage><pages>2647-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>In this study, we aimed to investigate the bone regeneration efficiency of two-layer porcine-derived bone scaffolds composed of cancellous and cortical bones in a rabbit calvarial defect model. Four circular calvaria defects were formed on cranium of rabbit and were filled with block bone scaffolds of each group: cortical bone block (Cortical group), cancellous bone block (Cancellous group), and two-layer bone block (2layer group). After 8 weeks, new bones were primarily observed in cancellous parts of the Cancellous and 2layer groups, while the Cortical group exhibited few new bones. In the results of new bone volume and area analyses, the Cancellous group showed the highest value, followed by the 2layer group, and were significantly higher than the Cortical group. Within the limitations of this study, the cancellous and two-layer porcine-derived bone scaffolds showed satisfactory bone regeneration efficiency; further studies on regulating the ratio of cortical and cancellous bones in two-layer bones are needed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>35269791</pmid><doi>10.3390/ijms23052647</doi><orcidid>https://orcid.org/0000-0002-9524-3835</orcidid><orcidid>https://orcid.org/0000-0002-2962-9553</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2022-02, Vol.23 (5), p.2647
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_17d880089ba8472b9bc529506aadcfec
source Publicly Available Content Database; PubMed Central(OpenAccess)
subjects Animals
Bone growth
Bone Regeneration
bone scaffold
Bones
Calvaria
Cancellous Bone
Cortical bone
Cranium
Defects
porcine
Porosity
Rabbits
Regeneration
Regeneration (physiology)
Scaffolds
Skin & tissue grafts
Skull
Surgery
Swine
Tissue Scaffolds
xenograft
title Bone Reconstruction Using Two-Layer Porcine-Derived Bone Scaffold Composed of Cortical and Cancellous Bones in a Rabbit Calvarial Defect Model
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A31%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Bone%20Reconstruction%20Using%20Two-Layer%20Porcine-Derived%20Bone%20Scaffold%20Composed%20of%20Cortical%20and%20Cancellous%20Bones%20in%20a%20Rabbit%20Calvarial%20Defect%20Model&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Seo,%20Yong-Ho&rft.date=2022-02-28&rft.volume=23&rft.issue=5&rft.spage=2647&rft.pages=2647-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms23052647&rft_dat=%3Cproquest_doaj_%3E2638712739%3C/proquest_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c478t-e7302193c4b50033a7c921c21eda4333b9ddcf6a5e0d273de2026efc40720b33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2637744452&rft_id=info:pmid/35269791&rfr_iscdi=true