Exosomal miR-92a Concentration in the Serum of Shift Workers

Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engag...

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Bibliographic Details
Published in:Applied sciences 2020-01, Vol.10 (2), p.430
Main Authors: Bracci, Massimo, Eléxpuru Zabaleta, Maria, Tartaglione, Maria Fiorella, Ledda, Caterina, Rapisarda, Venerando, Santarelli, Lory
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose tissue (brown)
bat activity
Biological clocks
Biomarkers
brown adipose tissue
circadian disruption
Daytime
Energy balance
Estrogens
Exosomes
Gene expression
Glucose
Homeostasis
Lipids
metabolic syndrome
Metabolism
mir-92a
night work
Nurses
Proteins
Questionnaires
Shift work
Sleep
Workers
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Summary:Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engaged in shift and daytime work. No significant metabolic alterations were shown between daytime and shift workers while a difference in serum exosomal miR-92a levels was found between the two groups. The lower levels of miR-92a in shift workers were suggestive of a higher brown adipose tissue activity compared with daytime workers. However, the possibility that other physiological and pathological processes may influence miR-92a cannot be ruled out. Our results suggest further investigations on brown adipose tissue activity and on miR-92a regulatory mechanisms, such as those related to the estrogen pathway, in shift workers.
ISSN:2076-3417
2076-3417
DOI:10.3390/app10020430