Prognostic significance of Cyclooxygenase-2 expression in colorectal adenoma and Adenocarcinoma: A clinicopathologic study

•High expression of COX-2 was observed in the cytoplasm of the neoplastic epithelial cells of colorectal adenocarcinoma and stromal cells of colorectal adenoma.•The epithelial COX-2 overexpression of colorectal adenocarcinoma was significantly associated with advanced features including moderate dif...

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Bibliographic Details
Published in:Human Pathology Reports 2023-03, Vol.31, p.300692, Article 300692
Main Authors: Ibrahim, Noor I., Shamsudin, Shazana H., Lee, Suk K., T. Sharif, Sharifah Emilia
Format: Article
Language:English
Subjects:
Colorectal adenocarcinoma
Colorectal adenoma
Colorectal cancer
COX-2
Prognostic biomarker
Tumor microenvironment
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Summary:•High expression of COX-2 was observed in the cytoplasm of the neoplastic epithelial cells of colorectal adenocarcinoma and stromal cells of colorectal adenoma.•The epithelial COX-2 overexpression of colorectal adenocarcinoma was significantly associated with advanced features including moderate differentiation, usual-type histology, deeper invasion, higher Astler Coller stage, positive nodal metastasis and lymphovascular invasion.•In colorectal adenoma, high epithelial COX-2 expression showed significant association with advanced age and smaller size, while stromal COX-2 overexpression was significantly associated with lower grade of dysplasia.•COX-2 is a new potential prognostic biomarker for colorectal adenocarcinoma and detection of colorectal adenoma via its role in the tumor microenvironment. A new prognostic biomarker for colorectal cancer (CRC) is imperative and cyclooxygenase-2 (COX-2) has the potential as a new candidate. We aimed to investigate the differential expression of COX-2 and its relationship with clinicopathological features of colorectal neoplasms. We retrospectively investigate 91 cases of colorectal adenoma and 215 cases of adenocarcinoma by immunohistochemical assessment of COX-2 expression in the neoplastic epithelial and stromal cells. The differential COX-2 expression and its association with clinicopathological features was statistically evaluated. Significantly high expression of COX-2 was observed in the cytoplasm of the epithelial cells of adenocarcinoma (66.0 %) and stromal cells of adenoma (50.5 %), whilst low expression was seen in the stromal cells of adenocarcinoma (5.1 %) and epithelial cells of adenoma (26.4 %), (P 
ISSN:2772-736X
2772-736X
DOI:10.1016/j.hpr.2023.300692