Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs

• Published in: Journal of Ophthalmology 2016-01, Vol.2016 (2016), p.739-744-099
• Main Authors: Tao, Yuan, Zhang, Miaomiao, Wang, Jianrong, Liu, Wei, Sun, Yan
• Format: Article
• Language: English
• Subjects: Comparative analysis; Complications and side effects; Demographics; Dosage and administration; Fluorouracil; Glaucoma; Methods; Mitomycin; Patient outcomes; Patients; Physiological aspects; Revisions; Studies; Success; Trabeculectomy
• ISSN: 2090-004X; 2090-0058
• DOI: 10.1155/2016/3762674

Background. To compare the efficacy of needle revision with 5-fluorouracil (5-FU) and mitomycin C (MMC) on dysfunctional filtration blebs shortly after trabeculectomy. Methods. It is a prospective randomized study comparing needle revision augmented with MMC or 5-FU for failed trabeculectomy blebs. Results. To date 71 patients (75 eyes) have been enrolled, 40 eyes in the MMC group and 35 in the 5-FU group. 68 patients (72 eyes) have completed 12-month follow-up, 38 eyes in the MMC group and 34 in the 5-FU group. The mean IOP before and that after needle revision in the MMC group were 26.5 ± 4.3 mmHg and 11.3 ± 3 .4 mmHg, respectively ( P < 0.05 ), and in the 5-FU group were 27.1 ± 3.8 mmHg and 10.9 ± 3.4 mmHg, respectively ( P < 0.05 ). At 12-month follow-up, complete success rates were 57.5% for MMC group and 34.3% for 5-FU group ( P = 0.042 ; log-rank test) and 75% and 60% ( P = 0.145 ; log-rank test), respectively, for the qualified success. Complication rates between the two groups were not statistically different ( P > 0.05 ). Conclusions. Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.