circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis

Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is elevated...

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Bibliographic Details
Published in:Cell death discovery 2021-11, Vol.7 (1), p.365-365, Article 365
Main Authors: Ma, Xueyou, Ying, Yufan, Sun, Jiazhu, Xie, Haiyun, Li, Jiangfeng, He, Liujia, Wang, Weiyu, Chen, Shiming, Shen, Haixiang, Yi, Jiahe, Luo, Jindan, Wang, Xiao, Zheng, Xiangyi, Liu, Ben, Xie, Liping
Format: Article
Language:English
Subjects:
631/80/84/2176
631/80/84/2336
692/699/67/589/1336
Apoptosis
Biochemistry
Biomedical and Life Sciences
Bladder cancer
Cancer
Cell Biology
Cell Cycle Analysis
Life Sciences
Mesenchyme
Metastases
Metastasis
miRNA
Phenotypes
Stem Cells
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Summary:Circular RNAs (circRNAs) play essential roles in human bladder cancer (BCa) development, however, unusual expression patterns and functional dysfunction of circRNAs in BCa have not been evaluated. In this study, we validated that circKDM4C (hsa_circ_0001839), derived from the KDM4C gene, is elevated in BCa cell lines as well as tissues. Functionally, overexpression of circKDM4C significantly enhances, and silencing of circKDM4C suppresses migration and invasion capabilities of BCa cells. Mechanistically, circKDM4C can directly interact with miR-200b-3p and miR-200c-3p as a miRNA sponge, which enhances the expression of ZEB1 and promotes mesenchymal phenotype. Conclusively, our findings indicate that circKDM4C may act as a pro-oncogenic factor in BCa invasion and metastasis via the circKDM4C/miR-200bc-3p/ZEB1 axis, which is a potential biomarker or therapeutic target for bladder cancer.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-021-00712-9