Biocontrol evaluation of extracts and a major component, clusianone, from Clusia fluminensisPlanch. Triana againstAedes aegypti

Studies evaluated the effects of hexanic extracts from the fruits and flowers ofClusia fluminensis and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti. The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not af...

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Bibliographic Details
Published in:Memórias do Instituto Oswaldo Cruz 2015-08, Vol.110 (5), p.629-635
Main Authors: Maria C Anholeti, Rodrigo C Duprat, Maria R Figueiredo, Maria AC Kaplan, Marcelo Guerra Santos, Marcelo S Gonzalez, Norman A Ratcliffe, Denise Feder, Selma R Paiva, Cicero B Mello
Format: Article
Language:English
Subjects:
Aedes aegypti
Clusia fluminensis
clusianone
larvicidal
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Summary:Studies evaluated the effects of hexanic extracts from the fruits and flowers ofClusia fluminensis and the main component of the flower extract, a purified benzophenone (clusianone), against Aedes aegypti. The treatment of larvae with the crude fruit or flower extracts from C. fluminensis did not affect the survival ofAe. aegypti (50 mg/L), however, the flower extracts significantly delayed development of Ae. aegypti. In contrast, the clusianone (50 mg/L) isolate from the flower extract, representing 54.85% of this sample composition, showed a highly significant inhibition of survival, killing 93.3% of the larvae and completely blocking development of Ae. aegypti. The results showed, for the first time, high activity of clusianone against Ae. aegypti that both killed and inhibited mosquito development. Therefore, clusianone has potential for development as a biopesticide for controlling insect vectors of tropical diseases. Future work will elucidate the mode of action of clusianone isolated from C. fluminensis.
ISSN:1678-8060
DOI:10.1590/0074-02760150103