Boron Chemistry for Medical Applications

Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a ne...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-02, Vol.25 (4), p.828
Main Authors: Ali, Fayaz, S Hosmane, Narayan, Zhu, Yinghuai
Format: Article
Language:English
Subjects:
Animals
Boron - chemistry
boron cluster
boron delivery agents for bnct
boron neutron capture therapy
Boron Neutron Capture Therapy - methods
boron-containing compounds
Carbon - chemistry
carborane
Humans
Hydrogen - chemistry
medical applications
Review
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Summary:Boron compounds now have many applications in a number of fields, including Medicinal Chemistry. Although the uses of boron compounds in pharmacological science have been recognized several decades ago, surprisingly few are found in pharmaceutical drugs. The boron-containing compounds epitomize a new class for medicinal chemists to use in their drug designs. Carboranes are a class of organometallic compounds containing carbon (C), boron (B), and hydrogen (H) and are the most widely studied boron compounds in medicinal chemistry. Additionally, other boron-based compounds are of great interest, such as dodecaborate anions, metallacarboranes and metallaboranes. The boron neutron capture therapy (BNCT) has been utilized for cancer treatment from last decade, where chemotherapy and radiation have their own shortcomings. However, the improvement in the already existing (BPA and/or BSH) localized delivery agents or new tumor-targeted compounds are required before realizing the full clinical potential of BNCT. The work outlined in this short review addresses the advancements in boron containing compounds. Here, we have focused on the possible clinical implications of the new and improved boron-based biologically active compounds for BNCT that are reported to have in vivo and/or in vitro efficacy.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25040828