POSSIBLE ASSOCIATION AS ENDOCRINOLOGICAL PATHOLOGY WITH AUTOIMMUNE COMPONENT BETWEEN TYPE 2 DIABETES MELLITUS AND CHRONIC LYMPHOCYTIC THYROIDITIS

• Published in: Revista medicală Română 2019-03, Vol.66 (1), p.55-59
• Main Authors: Oana-Andreea Parliţeanu, Dan Mircea Cheţa
• Format: Article
• Language: English
• Subjects: autoimmune; correlation; thyroiditis; type 2 diabetes
• ISSN: 1220-5478; 2069-606X
• DOI: 10.37897/RMJ.2019.1.11

Background. It is a well-established practice that after the onset of type 1 diabetes (T1DM) the next conditions to be checked are Hashimoto thyroiditis (HT) as well as celiac disease. In children, T1DM most frequently is associated with celiac disease and in adults it associates HT. Also we have seen a high association between type 2 diabetes (T2DM) and TH. Aims. The primary objective is to evaluate the possible relationship between type 2 diabetes (T2DM) and Hashimoto thyroiditis (HT), since the only correlation described until now is between T1DM and HT based on the autoimmune mechanism. The secondary end-point is to evaluate if there is a correlation between the characteristics of type 2 diabetes and autoimmune thyroiditis and if the metabolic component may be a factor of association. Methods. We designed a retrospective, observational research, enrolling patients from “Sanamed” Hospital from Bucharest. Between 2016 and 2017 in our clinic a number of 150 were enrolled: 50 only with T2DM, 50 only with HT and 50 with both T2DM and HT. Results. The main observations of the study were the following: the prevalence of obesity was higher in patients with T2DM (p < 0.001) than in the lot with HT (p < 0.001) but was present is both groups and this was consistent with the data that we encountered about insulin resistence in T2DM and TH; dyslipidemia was higher in the thyroiditis group (59%) than in the group of patients with T2DM (36%); also syslipidemia was correlated with hepatic steatosis (r = 0.34, p < 0.001); ischemic cardiac disease was more frequent in the HT group (p < 0.001) than in the diabetes group (p< 0.001); ischemic cardiac disease was correlated with the value of TPO antibodies (r = -0.25, p < 0.01); in the group that had both T2DM and HT, the HbA1c was correlated with pre-existing thyroid pathology (p < 0.001). Conclusion. We have reached the conclusion that there is an association between the characteristics of T2DM and HT, as well as an interaction between these two diseases, considering their metabolic component.