Association between Blood Omega-3 Index and Cognition in Typically Developing Dutch Adolescents

The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13-15 years is investigated. Baseline data fr...

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Bibliographic Details
Published in:Nutrients 2016-01, Vol.8 (1), p.13-13
Main Authors: van der Wurff, Inge S M, von Schacky, Clemens, Berge, Kjetil, Zeegers, Maurice P, Kirschner, Paul A, de Groot, Renate H M
Format: Article
Language:English
Subjects:
Adolescent
adolescents
Animals
Attention - drug effects
Autism
Brain research
Child development
cognition
Cognition & reasoning
Cognition - drug effects
Dietary Supplements
docosahexaneoic acid (DHA)
Double-Blind Method
Dyslexia
eicosapentaenoic acid (EPA)
Euphausiacea - chemistry
Executive function
Fatty acids
Fatty Acids, Omega-3 - blood
Fatty Acids, Omega-3 - pharmacology
Female
Humans
Male
Netherlands
Neuropsychological Tests
Observational studies
Omega-3 fatty acids
Omega-3 Index
Regression Analysis
Signal transduction
Teenagers
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Summary:The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13-15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = -0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu8010013