The Role of Liposomal CpG ODN on the Course of L. major Infection in BALB/C Mice

Historically, leishmanization is the most effective protective measure against Cutaneous Leishmaniasis (CL), CL lesion induced by leishmanization sometimes takes a long time to heal. Manipulation of leishmanization inoculums needed to induce a mild and acceptable CL lesion. The aim of this study was...

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Bibliographic Details
Published in:Iranian journal of parasitology 2010-03, Vol.5 (1), p.47-54
Main Authors: Hejazi, H, Tasbihi, M, Jaafari, Mr, Badiee, A, Pestechian, N, Javadi, A, Khamesipour, A
Format: Article
Language:English
Subjects:
BALB/c
Colleges & universities
CpG ODN
Deoxyribonucleic acid
DNA
Leishmania major
Leprosy
Liposome
Original
Proteins
Skin diseases
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Summary:Historically, leishmanization is the most effective protective measure against Cutaneous Leishmaniasis (CL), CL lesion induced by leishmanization sometimes takes a long time to heal. Manipulation of leishmanization inoculums needed to induce a mild and acceptable CL lesion. The aim of this study was to explore if liposomal form of CpG ODN (Cytosin phosphate Guanin Oligodeoxynucleotides) mixed with Leishmania major would induce a milder lesion size in Balb/c mice. This study was performed in Biotechnology Research Center, Mashhad, and Center for Research and Training in Skin Diseases and Leprosy, Tehran, Iran during 2008-2009. Different groups of BALB/c mice were subcutaneously (SC) inoculated with L. major mixed with liposomal form of CpG ODN, or L. major plus free CpG ODN, or L. major mixed with empty liposomes or L. major in PBS. The lesion onset and the size of lesion were recorded; the death rate was also monitored. Footpad thickness was significantly (P
ISSN:1735-7020
2008-238X