Arousal-based pupil modulation is dictated by luminance

Pupillometry has become a standard measure for assessing arousal state. However, environmental factors such as luminance, a primary dictator of pupillary responses, often vary across studies. To what degree does luminance interact with arousal-driven pupillary changes? Here, we parametrically assess...

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Bibliographic Details
Published in:Scientific reports 2022-01, Vol.12 (1), p.1390-11, Article 1390
Main Authors: Pan, Jasmine, Klímová, Michaela, McGuire, Joseph T., Ling, Sam
Format: Article
Language:English
Subjects:
631/477
631/477/2811
Acoustic Stimulation
Adolescent
Adult
Arousal
Arousal - physiology
Arousal - radiation effects
Cognition - physiology
Cognition - radiation effects
Cognitive ability
Cognitive load
Environmental factors
Female
Fixation, Ocular - physiology
Fixation, Ocular - radiation effects
Heart Rate - physiology
Heart Rate - radiation effects
Humanities and Social Sciences
Humans
Light
Male
multidisciplinary
Photic Stimulation
Pupil - physiology
Pupil - radiation effects
Science
Science (multidisciplinary)
Screen Time
Vision, Ocular - physiology
Vision, Ocular - radiation effects
Young Adult
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Summary:Pupillometry has become a standard measure for assessing arousal state. However, environmental factors such as luminance, a primary dictator of pupillary responses, often vary across studies. To what degree does luminance interact with arousal-driven pupillary changes? Here, we parametrically assessed luminance-driven pupillary responses across a wide-range of luminances, while concurrently manipulating cognitive arousal using auditory math problems of varying difficulty. At the group-level, our results revealed that the modulatory effect of cognitive arousal on pupil size interacts multiplicatively with luminance, with the largest effects occurring at low and mid-luminances. However, at the level of individuals, there were qualitatively distinct individual differences in the modulatory effect of cognitive arousal on luminance-driven pupillary responses. Our findings suggest that pupillometry as a measure for assessing arousal requires more careful consideration: there are ranges of luminance levels that are more ideal in observing pupillary differences between arousal conditions than others.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-05280-1