Assessment of In Vitro Release Testing Methods for Colloidal Drug Carriers: The Lack of Standardized Protocols

Although colloidal carriers have been in the pipeline for nearly four decades, standardized methods for testing their drug-release properties remain to be established in pharmacopeias. The in vitro assessment of drug release from these colloidal carriers is one of the most important parameters in th...

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Published in:Pharmaceutics 2024-01, Vol.16 (1), p.103
Main Authors: Gómez-Lázaro, Laura, Martín-Sabroso, Cristina, Aparicio-Blanco, Juan, Torres-Suárez, Ana Isabel
Format: Article
Language:English
Subjects:
Analysis
dialysis-based methods
Drug delivery systems
Drug dosages
drug release
Drugs
liposomes
microparticles
Molecular weight
nanoparticles
Product introduction
Quality control
Review
sample and separate techniques
Vehicles
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creator Gómez-Lázaro, Laura
Martín-Sabroso, Cristina
Aparicio-Blanco, Juan
Torres-Suárez, Ana Isabel
description Although colloidal carriers have been in the pipeline for nearly four decades, standardized methods for testing their drug-release properties remain to be established in pharmacopeias. The in vitro assessment of drug release from these colloidal carriers is one of the most important parameters in the development and quality control of drug-loaded nano- and microcarriers. This lack of standardized protocols occurs due to the difficulties encountered in separating the released drug from the encapsulated one. This review aims to compare the most frequent types of release testing methods (i.e., membrane diffusion techniques, sample and separate methods and in situ detection techniques) in terms of the advantages and disadvantages of each one and of the key parameters that influence drug release in each case.
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subjects Analysis
dialysis-based methods
Drug delivery systems
Drug dosages
drug release
Drugs
liposomes
microparticles
Molecular weight
nanoparticles
Product introduction
Quality control
Review
sample and separate techniques
Vehicles
title Assessment of In Vitro Release Testing Methods for Colloidal Drug Carriers: The Lack of Standardized Protocols
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