Quantitative Dixon and intravoxel incoherent motion diffusion magnetic resonance imaging parameters in lumbar vertebrae for differentiating aplastic anemia and acute myeloid leukemia

• Published in: Frontiers in oncology 2023-12, Vol.13, p.1277978
• Main Authors: Hou, Meidan, Huang, Yanan, Yan, Jinsong, Fan, Guoguang
• Format: Article
• Language: English
• Subjects: acute myeloid leukemia; aplastic anemia; intravoxel incoherent motion; MRI; Oncology; quantitative Dixon
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2023.1277978

We sought to evaluate the use of quantitative Dixon (Q-Dixon) and intravoxel incoherent motion diffusion imaging (IVIM) for the differential diagnosis of aplastic anemia (AA) and acute myeloid leukemia (AML). Between August 2021 and October 2023, we enrolled 68 diagnosed patients, including 36 patients with AA and 32 patients with AML, as well as 26 normal controls. All patients underwent 3-Tesla magnetic resonance imaging, which included IVIM and T2*-corrected Q-Dixon imaging at the L2-4 level. The iliac crest biopsy's pathology was used as the diagnostic criterion. The interobserver measurement repeatability was evaluated using the intraclass correlation coefficient (ICC). One-way analysis of variance, Spearman analysis, and receiver operating characteristic curve analysis were used. The fat fraction (FF) and perfusion fraction (f) values were statistically significantly different between the three groups ( < 0.001 and = 0.007). The FF and f values in the AA group were higher than those in the AML group. The true apparent diffusion coefficient (D) value was substantially negatively correlated to the FF and R2* values (r = -0.601, < 0.001; r = -0.336, = 0.002). The f value was positively correlated with both FF and pseudo-apparent diffusion coefficient (D*) values (r = 0.376, < 0.001; r = 0.263, = 0.017) and negatively correlated with the D value (r = -0.320, = 0.003). The FF and f values were negatively correlated with the degree of myelodysplasia (r = -0.597, < 0.001; r = -0.454, = 0.004), and the D value was positively correlated with the degree of myelodysplasia (r = 0.395, = 0.001). For the differential diagnosis of AA and AML, the Q-Dixon model's sensitivity (93.75%) and specificity (84%) confirmed that it outperformed the IVIM model. Q-Dixon parameters have the potential to be used as new biomarkers to differentiate AA from AML.