Increased Serum Leptin Level Predicts Bone Mineral Density in Hemodialysis Patients

Background. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual...

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Bibliographic Details
Published in:International journal of endocrinology 2020, Vol.2020 (2020), p.1-7
Main Authors: Hsu, Bang-Gee, Syu, Ru-Jiang, Kuo, Chiu-Huang, Lin, Yu-Li, Lai, Yu-Hsien, Wang, Chih-Hsien, Chen, Ming-Chun
Format: Article
Language:English
Subjects:
Age
Albumin
Analysis
Blood pressure
Body mass index
Body weight
Bone density
Bones
Creatinine
Density
Endocrinology
Enzymes
Fractures
Glucose
Health care
Hemodialysis
Immunoassay
Leptin
Medical research
Medicine, Experimental
Metabolism
Osteoporosis
Regression analysis
Standard deviation
Studies
Triglycerides
Urea
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Summary:Background. Leptin acts through the adipose-bone axis to regulate bone mineral density (BMD). This study evaluated the relationship between BMD and serum leptin levels in patients on hemodialysis. Methods. In this cross-sectional study including 98 hemodialysis patients, BMD was measured using dual energy X-ray absorptiometry of the lumbar vertebrae (L2–L4), and serum leptin levels were determined using an enzyme immunoassay. Results. There were 25 (25.5%), 13 (13.3%), and 60 (61.2%) patients with osteopenia, osteoporosis, and normal BMD, respectively. Advanced age P=0.017; decreased body mass index (BMI, P
ISSN:1687-8337
1687-8345
DOI:10.1155/2020/8451751