RSV Infection in Human Macrophages Promotes CXCL10/IP-10 Expression during Bacterial Co-Infection

Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms rema...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-12, Vol.18 (12), p.2654
Main Authors: Machado, Daniela, Hoffmann, Jonathan, Moroso, Marie, Rosa-Calatrava, Manuel, Endtz, Hubert, Terrier, Olivier, Paranhos-Baccalà, Glaucia
Format: Article
Language:English
Subjects:
acute lower respiratory infection
Bacteria
Bacteriology
Cell Line, Tumor
Cells, Cultured
Chemokine CXCL10 - genetics
Chemokine CXCL10 - metabolism
Children
co-infection
Coinfection - immunology
Communication
CXCL10 protein
Etiology
Human health and pathology
Humans
Immune response
Immune system
Immunology
Infectious diseases
Inflammatory diseases
Innate immunity
IP-10 protein
Life Sciences
Macrophages
Macrophages - immunology
Macrophages - microbiology
Macrophages - virology
Microbiology and Parasitology
Monocytes
Pediatrics
Pneumococcal Infections - immunology
Pulmonology and respiratory tract
Respiratory syncytial virus
respiratory syncytial virus (RSV)
Respiratory Syncytial Virus Infections - immunology
Streptococcus infections
Streptococcus pneumoniae (Sp)
Virology
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Summary:Respiratory syncytial virus (RSV), a major etiologic agent of acute lower respiratory infection constitutes the most important cause of death in young children worldwide. Viral/bacterial mixed infections are related to severity of respiratory inflammatory diseases, but the underlying mechanisms remain poorly understood. We have previously investigated the intracellular mechanisms that mediate the immune response in the context of influenza virus/ ( ) co-infection using a model of human monocyte-derived macrophages (MDMs). Here, we set up and characterized a similar model of MDMs to investigate different scenarios of RSV infection and co-infection with . Our results suggest that contributes to a faster and possibly higher level of CXCL10/IP-10 expression induced by RSV infection in human MDMs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18122654