Effects of smoking and smoking abstinence on spatial vision in chronic heavy smokers

• Published in: Scientific reports 2017-05, Vol.7 (1), p.1690-7, Article 1690
• Main Authors: Fernandes, Thiago Monteiro de Paiva, Almeida, Natalia Leandro de, Santos, Natanael Antonio dos
• Format: Article
• Language: English
• Subjects: 631/378/2613; 631/477/2811; Acuity; Adult; Ammonia; Carbon monoxide; Cerebrospinal fluid; Chronic exposure; Cigarette smoke; Cigarettes; Cognitive ability; Contrast Sensitivity - physiology; Female; Health risk assessment; Humanities and Social Sciences; Humans; Information processing; Male; Middle Aged; multidisciplinary; Nicotine; Pyridines; Science; Science (multidisciplinary); Smokers; Smoking; Smoking - adverse effects; Smoking Cessation; Space Perception - physiology; Toluene; Vision; Vision, Ocular - physiology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-017-01877-z

Cigarette smoke is a complex chemical mixture, involving health-damaging components such as carbon monoxide, ammonia, pyridine, toluene and nicotine. While cognitive functions have been well documented in heavy smokers, spatial vision has been less characterized. In the article, we investigated smoking effects through contrast sensitivity function (CSF), a rigorous procedure that measures the spatial vision. Data were recorded from 48 participants, a group of non-smokers (n = 16), a group of chronic and heavy cigarette smokers (n = 16) and deprived smokers (n = 16); age range 20–45 years. Sinewave gratings with spatial frequencies ranging from 0.25 to 20 cycles per degree were used. All subjects were free from any neurological disorder, identifiable ocular disease and had normal acuity. No abnormalities were detected in the fundoscopic examination and in the optical coherence tomography exam. Contrary to expectations, performance on CSF differed between groups. Both smokers and deprived smokers presented a loss of contrast sensitivity compared to non-smokers. Post-hoc analyses suggest that deprived smokers were less sensitive at all spatial frequencies. These results suggest that not only chronic exposure to cigarette compounds but also withdrawal from nicotine affected spatial vision. This highlights the importance of understanding diffuse effects of smoking compounds on visual spatial processing.