Relationships between correlated spikes, oxygen and LFP in the resting-state primate

Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simu...

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Bibliographic Details
Published in:NeuroImage (Orlando, Fla.) Fla.), 2022-02, Vol.247, p.118728-118728, Article 118728
Main Authors: Li, Jingfeng M., Acland, Benjamin T., Brenner, Alexander S., Bentley, William J., Snyder, Lawrence H.
Format: Article
Language:English
Subjects:
Animals
Brain - physiology
Brain architecture
Brain Mapping
Default mode network
Electrophysiological Phenomena
Electrophysiological recording
Functional connectivity
Functional magnetic resonance imaging
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Monkeys & apes
Neurohemodynamic coupling
Oxygen - blood
Oxygen polarography
Primates - physiology
Rest - physiology
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Summary:Resting-state functional MRI (rsfMRI) provides a view of human brain organization based on correlation patterns of blood oxygen level dependent (BOLD) signals recorded across the whole brain. The neural basis of resting-state BOLD fluctuations and their correlation remains poorly understood. We simultaneously recorded oxygen level, spikes, and local field potential (LFP) at multiple sites in awake, resting monkeys. Following a spike, the average local oxygen and LFP voltage responses each resemble a task-driven BOLD response, with LFP preceding oxygen by 0.5 s. Between sites, features of the long-range correlation patterns of oxygen, LFP, and spikes are similar to features seen in rsfMRI. Most of the variance shared between sites lies in the infraslow frequency band (0.01–0.1 Hz) and in the infraslow envelope of higher-frequency bands (e.g. gamma LFP). While gamma LFP and infraslow LFP are both strong correlates of local oxygen, infraslow LFP explains significantly more of the variance shared between correlated oxygen signals than any other electrophysiological signal. Together these findings are consistent with a causal relationship between infraslow LFP and long-range oxygen correlations in the resting state.
ISSN:1053-8119
1095-9572
DOI:10.1016/j.neuroimage.2021.118728