Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study

Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare neuroendocrine tumors characterized by hemodynamic instability, caused by the paroxysmal release of catecholamines. Patients may develop cardiovascular complications in the perioperative phase due to the massive release of catecholamines, part...

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Published in:World journal of surgical oncology 2023-06, Vol.21 (1), p.192-192, Article 192
Main Authors: Giuseppina, De Filpo, Gabriele, Parenti, Clotilde, Sparano, Giulia, Rastrelli, Elena, Rapizzi, Serena, Martinelli, Francesca, Amore, Benedetta, Badii, Prosperi, Paolo, Tonino, Ercolino, Massimo, Mannelli, Mario, Maggi, Letizia, Canu
Format: Article
Language:English
Subjects:
Adrenal Gland Neoplasms - pathology
Adrenal Gland Neoplasms - surgery
Analysis
Anesthesia
Beta blockers
Blood pressure
Cardiac arrhythmia
Care and treatment
Catecholamines
Catecholamines - pharmacology
Chromaffin cells
Complications
Diagnosis
Doxazosin - pharmacology
Drug dosages
Endocrine
Female
Gender
Health aspects
Hemodynamic monitoring
Hemodynamics
Humans
Instability
Kinases
Laparoscopy
Male
Middle Aged
Mortality
Multivariate analysis
Neuroendocrine tumors
Normetanephrine - pharmacology
Oncology
Paraganglioma
Paraganglioma - pathology
Paraganglioma - surgery
Patients
Pheochromocytoma
Pheochromocytoma - pathology
Pheochromocytoma - surgery
Retrospective Studies
Risk factors
Stability
Stability analysis
Statistical analysis
Surgery
Surgical outcomes
Tumors
Vascular Diseases
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Summary:Pheochromocytoma (PHEO) and paraganglioma (PGL) are rare neuroendocrine tumors characterized by hemodynamic instability, caused by the paroxysmal release of catecholamines. Patients may develop cardiovascular complications in the perioperative phase due to the massive release of catecholamines, particularly during anesthetic induction and surgical manipulation of the tumor. The aim of this retrospective study was to evaluate the risk factors involved in perioperative hemodynamic instability in patients who underwent surgery for chromaffin tumors. Forty patients (median age 55 [36.50-64.50]) undergone surgery for PHEO/abdominal PGL from January 2011 to December 2016 at the AOU Careggi (Florence, Italy) were retrospectively evaluated. Systolic, diastolic, and mean blood pressure were considered at baseline and during surgery. Patients with blood pressure steadily  133 mmHg, and/or intraoperative SBP > 127 mmHg and MBP > 90 mmHg, should be carefully monitored. A multidisciplinary
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-023-03072-z