Pathway-Wide Genetic Risks in Chlamydial Infections Overlap between Tissue Tropisms: A Genome-Wide Association Scan

Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection and can lead to tubal factor infertility, a disease characterised by fibrosis of the fallopian tubes. Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt/PI3...

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Bibliographic Details
Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-9
Main Authors: Holland, Martin J., de Vries, Henry J. C., Preston, Mark D., Ouburg, Sander, Roberts, Chrissy h., Morré, Servaas A.
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Cell cycle
Chlamydia
Chlamydia infections
Chlamydia trachomatis
Complications
Disease
Disease transmission
Fibrosis
G protein-coupled receptors
G proteins
Genetic aspects
Genomes
Genomics
Health aspects
Immune response
Infections
Infertility
Neurosciences
Pathology
Proteins
Risk factors
Scars
Signal transduction
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Womens health
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Summary:Chlamydia trachomatis is the most commonly diagnosed bacterial sexually transmitted infection and can lead to tubal factor infertility, a disease characterised by fibrosis of the fallopian tubes. Genetic polymorphisms in molecular pathways involving G protein-coupled receptor signalling, the Akt/PI3K cascade, the mitotic cell cycle, and immune response have been identified in association with the development of trachomatous scarring, an ocular form of chlamydia-related fibrotic pathology. In this case-control study, we performed genome-wide association and pathways-based analysis in a sample of 71 Dutch women who attended an STI clinic who were seropositive for Chlamydia trachomatis antibodies and 169 high-risk Dutch women who sought similar health services but who were seronegative. We identified two regions of within-gene SNP association with Chlamydia trachomatis serological response and found that GPCR signalling and cell cycle pathways were also associated with the trait. These pathway-level associations appear to be common to immunological sequelae of chlamydial infections in both ocular and urogenital tropisms. These pathways may be central mediators of human refractoriness to chlamydial diseases.
ISSN:0962-9351
1466-1861
DOI:10.1155/2018/3434101