Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga ( Inonotus obliquus ) Growing on Betula pendula and Betula pubescens

Chaga mushroom ( ) is a pathogenic fungus that grows mostly on birch species ( Roth and Ehrh.) and has traditionally been used as an anticancer medicine. This study aimed to compare the chemical composition and cytotoxic activity of chagas growing on both spp. on various cancer cell lines. The freez...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-08, Vol.17 (8), p.1013
Main Authors: Raal, Ain, Kaldmäe, Hedi, Kütt, Karin, Jürimaa, Katrin, Silm, Maidu, Bleive, Uko, Aluvee, Alar, Adamson, Kalev, Vester, Marili, Erik, Mart, Koshovyi, Oleh, Nguyen, Khan Viet, Nguyen, Hoai Thi, Drenkhan, Rein
Format: Article
Language:English
Subjects:
Antioxidants
Cells
Colon
Cytotoxicity
downy birch
Drug stores
Estonia
Ethanol
Fungi
glucans
inotodiol
Liver cancer
Pharmacy
Raw materials
silver birch
triterpenoids
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chaga mushroom ( ) is a pathogenic fungus that grows mostly on birch species ( Roth and Ehrh.) and has traditionally been used as an anticancer medicine. This study aimed to compare the chemical composition and cytotoxic activity of chagas growing on both spp. on various cancer cell lines. The freeze-dried extracts contained triterpenes inotodiol, lanosterol betulin, and betulinic acid typical to conks growing on species. The cytotoxic activity of chaga growing on and 80% ethanolic extracts against 31 human cancer cell lines was evaluated by a sulforhodamine B assay. Chaga extract showed moderate activity against all cancer cell lines examined; it did not result in high cytotoxicity (IC ≤ 20 µg/mL). The strongest inhibitions were observed with chaga (growing on ) extract on the HepG2 and CAL-62 cell line and with chaga (from ) extract on the HepG2 cell line, with IC values of 37.71, 43.30, and 49.99 μg/mL, respectively. The chaga extracts from exert somewhat stronger effects on most cancer cell lines studied than extracts, which can be attributed to a higher content of inotodiol in extracts. This study highlights the potential of chaga as a source of bioactive compounds with selective anticancer properties. To the best of our knowledge, this study is the first investigation of the chemical composition of parasitizing on .
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17081013