Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

The present study was designed to determine the effects of repeated-sprint exercise in moderate hypoxia on inflammatory, muscle damage, oxidative stress, and angiogenic growth factor responses among athletes. Ten male college track and field sprinters [mean ± standard error (SE): age, 20.9 ± 0.1 yea...

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Bibliographic Details
Published in:Frontiers in physiology 2019-08, Vol.10, p.844-844
Main Authors: Kasai, Nobukazu, Kojima, Chihiro, Sumi, Daichi, Ikutomo, Akiho, Goto, Kazushige
Format: Article
Language:English
Subjects:
angiogenic growth factor
hypoxic exercise
inflammation
maximal sprint
Physiology
track and field sprinters
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Summary:The present study was designed to determine the effects of repeated-sprint exercise in moderate hypoxia on inflammatory, muscle damage, oxidative stress, and angiogenic growth factor responses among athletes. Ten male college track and field sprinters [mean ± standard error (SE): age, 20.9 ± 0.1 years; height, 175.7 ± 1.9 cm; body weight, 67.3 ± 2.0 kg] performed two exercise trials in either hypoxia [HYPO; fraction of inspired oxygen (F O ), 14.5%] or normoxia (NOR; F O , 20.9%). The exercise consisted of three sets of 5 s × 6 s maximal sprints with 30 s rest periods between sprints and 10 min rest periods between sets. After completing the exercise, subjects remained in the chamber for 3 h under the prescribed oxygen concentration (hypoxia or normoxia). The average power output during exercise did not differ significantly between trials ( = 0.17). Blood lactate concentrations after exercise were significantly higher in the HYPO trial than in the NOR trial ( < 0.05). Plasma interleukin-6 concentrations increased significantly after exercise ( < 0.01), but there was no significant difference between the two trials ( = 0.07). Post-exercise plasma interleukin-1 receptor antagonist, serum myoglobin, serum lipid peroxidation, plasma vascular endothelial growth factor (VEGF), and urine 8-hydroxydeoxyguanosine concentrations did not differ significantly between the two trials ( > 0.05). In conclusion, exercise-induced inflammatory, muscle damage, oxidative stress, and VEGF responses following repeated-sprint exercise were not different between hypoxia and normoxia.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2019.00844