Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding -propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549,...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-05, Vol.26 (11), p.3249
Main Authors: Luo, Han, Lv, Yong-Feng, Zhang, Hong, Hu, Jiang-Miao, Li, Hong-Mei, Liu, Shou-Jin
Format: Article
Language:English
Subjects:
A549 Cells
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - pharmacology
Antitumor activity
Apoptosis
Aqueous solutions
Azide
Azides - pharmacology
Cell growth
Cell Line, Tumor
Chromatography
Cycloaddition
Cytotoxicity
Drug Screening Assays, Antitumor
Gene expression
HL-60 Cells
Humans
Inhibitory Concentration 50
Kinases
Liver cancer
Magnetic Resonance Spectroscopy
MCF-7 Cells
Molecular Structure
mollugin
Pyrans - chemistry
Solvents
Structure-Activity Relationship
synthesis
Triazoles
Triazoles - chemistry
Tumor cell lines
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Summary:A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding -propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds and exhibited significant cytotoxicity of all five cancer cell lines.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26113249