Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature

Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently...

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Bibliographic Details
Published in:Radiology case reports 2025-01, Vol.20 (1), p.158-161
Main Authors: Ben Abdelhafidh, Hiba, Ben Rejeb, Oumayma, Rouis, Nour, Bannour, Badra, Fathallah, Neila, Bannour, Imen
Format: Article
Language:English
Subjects:
Case Report
Femoral agenesis
Follow-up ultrasound
Misoprostol
Teratogenicity
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Summary:Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development. We present a rare case of femoral agenesis observed in a woman who experienced a failed medical abortion with Misoprostol (Cytotec®), highlighting the need for a better understanding of the risks associated with fetal exposure to this drug and the implementation of rigorous follow-up measures after its use.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2024.09.133