Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature

Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently...

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Published in:Radiology case reports 2025-01, Vol.20 (1), p.158-161
Main Authors: Ben Abdelhafidh, Hiba, Ben Rejeb, Oumayma, Rouis, Nour, Bannour, Badra, Fathallah, Neila, Bannour, Imen
Format: Article
Language:English
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Case Report
Femoral agenesis
Follow-up ultrasound
Misoprostol
Teratogenicity
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container_title Radiology case reports
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creator Ben Abdelhafidh, Hiba
Ben Rejeb, Oumayma
Rouis, Nour
Bannour, Badra
Fathallah, Neila
Bannour, Imen
description Misoprostol, a synthetic analogue of prostaglandin E1, is commonly used in gynecology, particularly in combination with mifepristone for elective abortion. Although its use is widespread, the potential teratogenic effects of misoprostol in cases of failed medical abortion have not been sufficiently explored in the medical literature. Severe congenital malformations, although rare, have been reported, raising concerns about the impact of this drug on fetal development. We present a rare case of femoral agenesis observed in a woman who experienced a failed medical abortion with Misoprostol (Cytotec®), highlighting the need for a better understanding of the risks associated with fetal exposure to this drug and the implementation of rigorous follow-up measures after its use.
doi_str_mv 10.1016/j.radcr.2024.09.133
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subjects Case Report
Femoral agenesis
Follow-up ultrasound
Misoprostol
Teratogenicity
title Teratogenic effect of Misoprostol following failure of elective abortion: A case of femoral agenesis and review of the literature
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