Association of chronic heart failure with mortality in old intensive care patients suffering from Covid‐19

Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID‐19). This prospective international multicentre study investigates the role of pre‐existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID‐19. Metho...

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Published in:ESC Heart Failure 2022-06, Vol.9 (3), p.1756-1765
Main Authors: Bruno, Raphael Romano, Wernly, Bernhard, Wolff, Georg, Fjølner, Jesper, Artigas, Antonio, Bollen Pinto, Bernardo, Schefold, Joerg C., Kindgen‐Milles, Detlef, Baldia, Philipp Heinrich, Kelm, Malte, Beil, Michael, Sviri, Sigal, Heerden, Peter Vernon, Szczeklik, Wojciech, Topeli, Arzu, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Kondili, Eumorfia, Marsh, Brian, Andersen, Finn H., Moreno, Rui, Leaver, Susannah, Boumendil, Ariane, De Lange, Dylan W., Guidet, Bertrand, Flaatten, Hans, Jung, Christian
Format: Article
Language:English
Subjects:
Cardiovascular disease
Chronic Disease
Coronaviruses
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
Critical Care
Critical Illness
Elderly
Heart failure
Heart Failure - complications
Heart Failure - epidemiology
Hospitalization
Humans
Mortality
Original
Prognosis
Prospective Studies
Stroke Volume
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Summary:Aims Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID‐19). This prospective international multicentre study investigates the role of pre‐existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID‐19. Methods and results Patients with pre‐existing CHF were subclassified as having ischaemic or non‐ischaemic cardiac disease; patients with a documented ejection fraction (EF) were subclassified according to heart failure EF: reduced (HFrEF, n = 132), mild (HFmrEF, n = 91), or preserved (HFpEF, n = 103). Associations of heart failure characteristics with the 30 day mortality were analysed in univariate and multivariate logistic regression analyses. Pre‐existing CHF was reported in 566 of 3917 patients (14%). Patients with CHF were older, frailer, and had significantly higher SOFA scores on admission. CHF patients showed significantly higher crude 30 day mortality [60% vs. 48%, P 
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.13854