Urine Monocyte Chemoattractant Protein-1 and Lupus Nephritis Disease Activity: Preliminary Report of a Prospective Longitudinal Study

Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN—active or inac...

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Bibliographic Details
Published in:Autoimmune Diseases 2015-01, Vol.2015 (2015), p.119-131
Main Authors: Ba’in, Arbaiyah, Shah, Shamsul Azhar, Mohd, Marlyn, Kong, Norella C. T., Alharazy, Sabah, Abdul Gafor, Abdul Halim
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Cellular proteins
Creatinine
Development and progression
Genetic aspects
Health aspects
Kidney diseases
Laboratories
Longitudinal studies
Lupus
Lupus nephritis
Monocyte chemoattractant protein
Monocyte chemoattractant protein 1
Monocytes
Mortality
Nephritis
Patients
Proteins
Proteinuria
Renal function
Sediments
Tumor necrosis factor-TNF
Urinalysis
Urine
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Summary:Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN—active or inactive—had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and 4 months. Urinary parameters, renal function test, serological markers, and renal SLE disease activity index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uMCP-1. Results. A hundred patients completed the study. At each visit, uMCP-1 levels (pg/mg creatinine) were significantly higher in the active group especially with relapses and were significantly associated with proteinuria and renal SLEDAI-2K. Receiver operating characteristic (ROC) curves showed that uMCP-1 was a potential biomarker for LN. Whereas multiple logistic regression analysis showed that only proteinuria and serum albumin and not uMCP-1 were independent predictors of LN activity. Conclusion. uMCP-1 was increased in active LN. Although uMCP-1 was not an independent predictor for LN activity, it could serve as an adjunctive marker when the clinical diagnosis of LN especially early relapse remains uncertain. Larger and longer studies are indicated.
ISSN:2090-0430
2090-0422
2090-0430
DOI:10.1155/2015/962046