Glucocorticoid management of adrenal insufficiency in the United Kingdom: assessment using real-world data

Background and objectives Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment. Methods We used 2010–2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses...

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Bibliographic Details
Published in:Endocrine Connections 2019-01, Vol.8 (1), p.20-31
Main Authors: Iqbal, Kamran, Halsby, Kate, Murray, Robert D, Carroll, Paul V, Petermann, Robert
Format: Article
Language:English
Subjects:
adrenal insufficiency
hydrocortisone
modified-release
outcome
resource
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Summary:Background and objectives Glucocorticoids are used to manage adrenal insufficiency (AI). We describe treatments used in the United Kingdom and real-world clinical outcomes for each treatment. Methods We used 2010–2016 primary care data from The Health Improvement Network (THIN). Descriptive analyses were conducted, and differences in variables between patients prescribed immediate-release hydrocortisone (IR HC), prednisolone or modified-release hydrocortisone (MR HC) were assessed using Fisher’s exact test. Results Overall, 2648 patients were included: 1912 on IR HC (72%), 691 on prednisolone (26%) and 45 (2%) on MR HC. A total of 1174 (44.3%) had primary and 1150 (43.4%) had secondary AI. Patients on prednisolone were older (P 
ISSN:2049-3614
2049-3614
DOI:10.1530/EC-18-0418