Gonadotropin treatment for male partial congenital hypogonadotropic hypogonadism in Chinese patients

Partial congenital hypogonadotropic hypogonadism (PCHH) is caused by an insufficiency in, but not a complete lack of, gonadotropin secretion. This leads to reduced testosterone production, mild testicular enlargement, and partial pubertal development. No studies have shown the productivity of sperma...

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Bibliographic Details
Published in:Asian journal of andrology 2020-07, Vol.22 (4), p.390-395
Main Authors: Hao, Ming, Nie, Min, Yu, Bing-Qing, Gao, Yin-Jie, Wang, Xi, Ma, Wan-Lu, Huang, Qi-Bin, Zhang, Rui, Mao, Jiang-Feng, Wu, Xue-Yan
Format: Article
Language:English
Subjects:
Care and treatment
Cryptorchidism
Deoxyribonucleic acid
DNA
Genes
Genetic testing
gonadotropin treatment
partial congenital hypogonadotropic hypogonadism
spermatogenesis
Gonadotropins
Hormones
Hypogonadism
Infertility
Medical research
Medical schools
Original
Patients
Puberty
Sperm
Spermatogenesis
Testosterone
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Summary:Partial congenital hypogonadotropic hypogonadism (PCHH) is caused by an insufficiency in, but not a complete lack of, gonadotropin secretion. This leads to reduced testosterone production, mild testicular enlargement, and partial pubertal development. No studies have shown the productivity of spermatogenesis in patients with PCHH. We compared the outcomes of gonadotropin-induced spermatogenesis between patients with PCHH and those with complete congenital hypogonadotropic hypogonadism (CCHH). This retrospective study included 587 patients with CHH who were treated in Peking Union Medical College Hospital (Beijing, China) from January 2008 to September 2016. A total of 465 cases were excluded from data analysis for testosterone or gonadotropin-releasing hormone treatment, cryptorchidism, poor compliance, or incomplete medical data. We defined male patients with PCHH as those with a testicular volume of ≥4 ml and patients with a testicular volume of
ISSN:1008-682X
1745-7262
DOI:10.4103/aja.aja_88_19