Elesesterpenes A-K: Lupane-type Triterpenoids From the Leaves of Eleutherococcus sessiliflorus

Elesesterpenes A-K ( - ), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of . Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The abso...

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Published in:Frontiers in chemistry 2022-01, Vol.9, p.813764-813764
Main Authors: Han, Dong, Liu, Yan, Li, Xiao-Mao, Wang, Si-Yi, Sun, Yan, Algradi, Adnan Mohammed, Zou, Hai-Dan, Pan, Juan, Guan, Wei, Kuang, Hai-Xue, Yang, Bing-You
Format: Article
Language:English
Subjects:
anti-inflammatory
antiproliferative
Chemistry
Eleutherococcus sessiliflorus
nortriterpenoid
triterpenoid glycosides
triterpenoids
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Summary:Elesesterpenes A-K ( - ), eleven new lupane-type triterpenoids, triterpenoid glycosides, and nortriterpenoid were isolated from the leaves of . Their structures and relative configurations were completely elucidated by a combination of diverse methods including physical, spectroscopic data. The absolute configuration of elesesterpenes A-B ( - ) was defined by single-crystal X-ray diffraction. Meanwhile, all the isolates were evaluated for anti-inflammatory activities on lipopolysaccharide-induced nitric oxide production in BV2 microglial cells, and antiproliferative activities against human hepatoma (HepG2), human lung adenocarcinoma (A549), and human glioma cells (LN229) . It was found that some of them exhibited obvious anti-inflammatory activities and potent antiproliferative activities.
ISSN:2296-2646
2296-2646
DOI:10.3389/fchem.2021.813764