Lactiplantibacillus plantarum L47 and inulin affect colon and liver inflammation in piglets challenged by enterotoxigenic Escherichia coli through regulating gut microbiota

Infection by pathogenic bacteria during weaning is a common cause of diarrhea and intestinal inflammation in piglets. Supplementing the diet with synbiotics is beneficial for animal health. The strain of L47 (L47) isolated in our lab exhibited good probiotic properties when combined with inulin. Her...

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Bibliographic Details
Published in:Frontiers in veterinary science 2024-11, Vol.11, p.1496893
Main Authors: Miao, Jingna, Cui, Leihong, Zeng, Hui, Hou, Meixin, Wang, Jingxuan, Hang, Suqin
Format: Article
Language:English
Subjects:
colon
enterotoxigenic Escherichia coli
inulin
Lactiplantibacillus plantarum L47
liver
Veterinary Science
weaned piglet
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Summary:Infection by pathogenic bacteria during weaning is a common cause of diarrhea and intestinal inflammation in piglets. Supplementing the diet with synbiotics is beneficial for animal health. The strain of L47 (L47) isolated in our lab exhibited good probiotic properties when combined with inulin. Here, the effectiveness of combining L47 and inulin (CLN) in protecting against enterotoxigenic (ETEC) induced colon and liver inflammation in weaned piglets was evaluated. Twenty-eight piglets aged 21 days were randomly assigned into 4 groups: CON (control), LI47 (oral CLN culture fluid, 10  CFU/d of L47 and 1 g/d of inulin), ECON (oral ETEC culture fluid, 10  CFU/d), and ELI47 (oral CLN and ETEC culture fluid). After 24 days, the colon and liver samples were collected for further analysis. CLN alleviated colon damage caused by ETEC challenge, as evidenced by an increase of colonic crypt depth, mRNA expression of tight junction and , GPX activity, the concentration of IL-10 and sIgA (  
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2024.1496893