First Pregnancy, Somatic and Psychological Status of a 4-Year-Old Child Born following Annexin V TESA Sperm Separation

Abstract Introduction  Sperm DNA integrity is a crucial paternal factor affecting fertilization and pregnancy rates, as well as embryo development. Case  The present case report describes the successful pregnancy after testicular sperm aspiration (TESA) combined with intracytoplasmic sperm injection...

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Bibliographic Details
Published in:American journal of perinatology reports 2015-10, Vol.5 (2), p.e105-e108
Main Authors: Lukaszuk, Krzysztof, Wcislo, Monika, Liss, Joanna, Stachowicz, Anna, Jakiel, Grzegorz, Lukaszuk, Mariusz, Pastuszek, Ewa, Woclawek-Potocka, Izabela, Galvao, Antonio, Bialobrzeska, Dorota
Format: Article
Language:English
Subjects:
Case Report
intracytoplasmic sperm injection
sperm
sperm dna integrity
testicular sperm aspiration
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Summary:Abstract Introduction  Sperm DNA integrity is a crucial paternal factor affecting fertilization and pregnancy rates, as well as embryo development. Case  The present case report describes the successful pregnancy after testicular sperm aspiration (TESA) combined with intracytoplasmic sperm injection (ICSI) (TESA-ICSI) in a couple where the male presented high sperm DNA fragmentation. In order to sort damaged sperm presenting DNA fragmentation, magnetic activated cell sorting (MACS) with annexin V microbeads (MACS Miltenyi Biotec, Teterow, Germany) was used. Conclusion  The authors present the first description of a successful medical case using TESA-ICSI annexin V sperm sorting. Additionally, a follow-up of the child at the age of 4 years old was done.
ISSN:2157-6998
2157-7005
DOI:10.1055/s-0035-1548726