The Role of the lncRNA MALAT1 in Neuroprotection against Hypoxic/Ischemic Injury

Hypoxic and ischemic brain injury can cause neurological disability and mortality, and has become a serious public health problem worldwide. Long-chain non-coding RNAs are involved in the regulation of many diseases. Metastasis-related lung adenocarcinoma transcript 1 (MALAT1) is a type of long non-...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2022-01, Vol.12 (1), p.146
Main Authors: Wang, Liping, Li, Sijie, Stone, Sara Saymuah, Liu, Na, Gong, Kerui, Ren, Changhong, Sun, Kai, Zhang, Chunyang, Shao, Guo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Angiogenesis
Animals
Apoptosis
Autophagy
Brain injury
Cell division
Cognitive ability
DNA methylation
Epigenetics
Gene expression
Hypoxia
Hypoxia - genetics
hypoxic/ischemic injury
Inflammation
Ischemia
Lung cancer
Lung diseases
MALAT1
Metastases
Mice
Mice, Inbred C57BL
MicroRNAs
Nervous system
Neurological complications
neuronal cell
Neuroprotection
Neuroprotection - genetics
Non-coding RNA
protection
Proteins
Public health
Review
RNA polymerase
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Therapeutic targets
Transcription
Transcription factors
Traumatic brain injury
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Summary:Hypoxic and ischemic brain injury can cause neurological disability and mortality, and has become a serious public health problem worldwide. Long-chain non-coding RNAs are involved in the regulation of many diseases. Metastasis-related lung adenocarcinoma transcript 1 (MALAT1) is a type of long non-coding RNA (lncRNA), known as long intergenic non-coding RNA (lincRNA), and is highly abundant in the nervous system. The enrichment of MALAT1 in the brain indicates that it may be associated with important functions in pathophysiological processes. Accordingly, the role of MALAT1 in neuronal cell hypoxic/ischemic injury has been gradually discovered over recent years. In this article, we summarize recent research regarding the neuroprotective molecular mechanism of MALAT1 and its regulation of pathophysiological processes of brain hypoxic/ischemic injury. MALAT1 may function as a regulator through interaction with proteins or RNAs to perform its role, and may therefore serve as a therapeutic target in cerebral hypoxia/ischemia.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom12010146