Update on Rapid Diagnostics for COVID-19: A Systematic Review

An accurate and rapid diagnosis of COVID-19 is an effective strategy for pandemic control, allowing disease screening and timely therapeutic intervention. We analyzed scientific reports about rapid tests for the diagnosis of COVID-19 to assess their reliability parameters. Medical Subject Headings t...

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Bibliographic Details
Published in:International journal of translational medicine 2022-06, Vol.2 (2), p.252-274
Main Authors: de Paula Dias, Bruna, Gonçalves, Ricardo Lemes, Ferreira, Cyntia Silva, Barbosa, Camila Cavadas, Arrieta, Orlando Alfredo Pineda, dos Santos, Samara Mayra Soares Alves, Malta, Wellington Carvalho, Alves e Silva, Mariela, Gomes, Maria Laura Maximiano Dias, Guimarães, Adriana Gibara, Borges, Lysandro Pinto, de Mello Silva, Breno
Format: Article
Language:English
Subjects:
Accuracy
Antigens
Coronaviruses
COVID-19
Immunoglobulins
Infections
Influenza
Medical screening
Pandemics
Pathogens
point-of-care
rapid diagnostic tests
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Systematic review
Viruses
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Summary:An accurate and rapid diagnosis of COVID-19 is an effective strategy for pandemic control, allowing disease screening and timely therapeutic intervention. We analyzed scientific reports about rapid tests for the diagnosis of COVID-19 to assess their reliability parameters. Medical Subject Headings terms or keywords related to point-of-care and rapid diagnostic testing for SARS-CoV-2 and COVID-19 were searched in data published from November 2020 to November 2021 in PubMed and Google Scholar databases. Notable differences were observed in sensitivity among direct tests that used different samples, and good accuracy was reported in a significant number of studies (>80%). Pediatric samples and samples with high Ct values (RT-PCR) had suboptimal sensitivity (range 45.4% to 66%). Further, a lack of sensitivity (60%). For serological detection of IgM or Antigen rapid diagnostic tests, no cross-reactivity was found with other coronaviruses. Therefore, although these tests are very important in facing the pandemic, they still need to be improved to test cross-reactivity against other pathogens, especially against other coronaviruses.
ISSN:2673-8937
2673-8937
DOI:10.3390/ijtm2020023