Arrhythmia onsets triggered by acute myocardial ischemia are not mediated by lysophosphoglycerides accumulation in ventricular myocardium

• Published in: Scientific reports 2024-04, Vol.14 (1), p.9589-9589, Article 9589
• Main Authors: Liu, Jiawei, Mai, Tingting, Ren, Han, Chang, Yafei, Li, Chao, Lv, Guoli, Zheng, Da, Liao, Xinbiao, Yu, Yangeng, Zhang, Fu, Zhao, Shuquan, Liu, Xiaoshan, Liu, Shuiping, Zhao, Hu, Luo, Bin, Liu, Chao, Huang, Erwen
• Format: Article
• Language: English
• Subjects: 692/4019; 692/4019/592; Accumulation; Aconitine - analogs & derivatives; Animals; Arrhythmia; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - metabolism; Cardiac arrhythmia; Cardiovascular disease; Cardiovascular diseases; Cell death; Coronary artery disease; Disease Models, Animal; Heart diseases; Heart Ventricles - metabolism; Heart Ventricles - pathology; Humanities and Social Sciences; Humans; Ischemia; Male; Mortality; multidisciplinary; Myocardial infarction; Myocardial ischemia; Myocardial Ischemia - metabolism; Myocardial Ischemia - pathology; Myocardium; Myocardium - metabolism; Myocardium - pathology; Ouabain; Ouabain - metabolism; Ouabain - pharmacology; Rats; Science; Science (multidisciplinary); Ventricle; Ventricular Fibrillation - etiology; Ventricular Fibrillation - metabolism; Ventricular Fibrillation - pathology
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-57047-5

Lysophosphoglycerides (LPLs) have been reported to accumulate in myocardium and serve as a cause of arrhythmias in acute myocardial ischemia. However, in this study we found that LPLs level in the ventricular myocardium was decreased by the onset of acute myocardial ischemia in vivo in rats. Decreasing of LPLs level in left ventricular myocardium, but not right, was observed within 26 min of left myocardial ischemia, regardless of whether arrhythmias were triggered. Lower LPLs level in the ventricular myocardium was also observed in aconitine-simulated ventricular fibrillation ( P