The effectiveness of newly synthesized quaternary ammonium salts differing in chain length and type of counterion against priority human pathogens

Quaternary ammonium salts (QAS) commonly occur as active substances in disinfectants. QAS have the important property of coating abiotic surfaces, which prevents adhesion of microorganisms, thus inhibiting biofilm formation. In this study, a group of nine monomeric QAS, differing in the structure an...

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Bibliographic Details
Published in:Scientific reports 2022-12, Vol.12 (1), p.21799-18, Article 21799
Main Authors: Kula, Natalia, Lamch, Łukasz, Futoma-Kołoch, Bożena, Wilk, Kazimiera A., Obłąk, Ewa
Format: Article
Language:English
Subjects:
631/326/22
631/326/421
Acetic acid
Adhesion
Ammonium
Ammonium salts
Animals
Biofilms
Blood cells
Disinfectants
Disinfectants - pharmacology
Hemolysis
Humanities and Social Sciences
Humans
Hydrophobicity
Microorganisms
multidisciplinary
Mutagenicity
Polystyrene
Quaternary Ammonium Compounds - chemistry
Quaternary Ammonium Compounds - pharmacology
Salts - chemistry
Salts - pharmacology
Science
Science (multidisciplinary)
Sheep
Silicones
Stainless Steel
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Summary:Quaternary ammonium salts (QAS) commonly occur as active substances in disinfectants. QAS have the important property of coating abiotic surfaces, which prevents adhesion of microorganisms, thus inhibiting biofilm formation. In this study, a group of nine monomeric QAS, differing in the structure and length of the aliphatic chain (C12, C14, C16) and the counterion (methylcarbonate, acetate, bromide), were investigated. The study included an analysis of their action against planktonic forms as well as bacterial biofilms. The compounds were tested for their anti-adhesion properties on stainless steel, polystyrene, silicone and glass surfaces. Moreover, mutagenicity analysis and evaluation of hemolytic properties were performed. It was found that compounds with 16-carbon hydrophobic chains were the most promising against both planktonic forms and biofilms. Tested surfactants (C12, C14, C16) showed anti-adhesion activity but it was dependent on the type of the surface and strain used. The tested compounds at MIC concentrations did not cause hemolysis of sheep blood cells. The type of counterion was not as significant for the activity of the compound as the length of the hydrophobic aliphatic chain.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24760-y