A ＂Proteoglycan Targeting Strategy＂ for the Scintigraphic Imaging and Monitoring of the Swarm Rat Chondrosarcoma Orthotopic Model

Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated ani...

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Bibliographic Details
Published in:Sarcoma 2011-01, Vol.2011 (2011), p.366-373
Main Authors: Peyrode, Caroline, Gouin, François, Vidal, Aurélien, Auzeloux, Philippe, Besse, Sophie, Dauplat, Marie-Mélanie, Askienazy, Serge, Heymann, Dominique, Chezal, Jean-Michel, Redini, Françoise, Miot-Noirault, Elisabeth
Format: Article
Language:English
Subjects:
Cancer
Chondrosarcoma
Diagnosis
Health aspects
Methods
Proteoglycans
Radioisotope scanning
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Summary:Our lab developed 99mTc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of 99mTc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (SRC). 99mTc-NTP 15-5 imaging of SRC-bearing and sham-operated animals was performed and quantified at regular intervals after surgery and compared to bone scintigraphy and tumoural volume. Tumours were characterized by histology and PG assay. SRC exhibited a significant 99mTc-NTP 15-5 uptake at very early stage after implant (with tumour/muscle ratio of 1.61 ± 0.14), whereas no measurable tumour was evidenced. As tumour grew, mean tumour/muscle ratio was increased by 2.4, between the early and late stage of pathology. Bone scintigraphy failed to image chondrosarcoma, even at the later stage of study. 99mTc-NTP 15-5 imaging provided a suitable set of quantitative criteria for the in vivo characterization of chondrosarcoma behaviour in bone environment, useful for achieving a greater understanding of the pathology.
ISSN:1357-714X
1369-1643
DOI:10.1155/2011/691608