Association between D-dimer-to-albumin ratio and 28-days all-cause mortality in patients with sepsis

We aimed to investigate the correlation between the serum D-dimer (D-D) to albumin (ALB) ratio (DAR) and 28-day all-cause mortality in patients with sepsis. Data from sepsis patients admitted to the intensive care unit (ICU) of Wuhan Fourth Hospital from October 2021 to January 2024 were collected....

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Bibliographic Details
Published in:Scientific reports 2024-11, Vol.14 (1), p.28361-14, Article 28361
Main Authors: Lu, Jing, Fang, Weizhi, Lei, Yu, Yang, Jie
Format: Article
Language:English
Subjects:
28-day mortality
692/699/255/1318
692/699/255/1578
692/699/255/2514
Aged
Albumin
Biomarkers - blood
D-dimer
D-dimer to albumin ratio
Death
Female
Fibrin Fibrinogen Degradation Products - analysis
Fibrin Fibrinogen Degradation Products - metabolism
Health risks
Humanities and Social Sciences
Humans
Intensive Care Units
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Mortality factors
Mortality risk
multidisciplinary
Patients
Prognosis
Proportional Hazards Models
Regression analysis
Retrospective Studies
Risk Factors
Risk reduction
ROC Curve
Science
Science (multidisciplinary)
Sepsis
Sepsis - blood
Sepsis - mortality
Serum Albumin - analysis
Serum Albumin - metabolism
Survival
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Summary:We aimed to investigate the correlation between the serum D-dimer (D-D) to albumin (ALB) ratio (DAR) and 28-day all-cause mortality in patients with sepsis. Data from sepsis patients admitted to the intensive care unit (ICU) of Wuhan Fourth Hospital from October 2021 to January 2024 were collected. Univariate cox analysis was performed for mortality factors in sepsis patients, and multiple cox regression models were used to analyze independent mortality risk factors. The receiver operating characteristics (ROC) curve was used to analyze the value of DAR in predicting sepsis mortality, and the Kaplan–Meier method was used to plot the survival curve. A total of 833 patients with sepsis in the ICU of our hospital were selected and divided into alive group ( n  = 574) and death group ( n  = 171) according to their 28-day survival. In the death group, D-D and DAR levels were higher, while ALB levels was lower than in the alive group. Spearman analysis found that DAR level were positively correlated with APACHE II and SOFA scores. Multivariate cox regression analysis showed that DAR was an independent predictor of all-cause mortality within 28 days of admission for sepsis patients (HR = 17.956, 95% CI 3.435–93.851, p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-79911-0