Microfluidics as a Novel Technique for Tuberculosis: From Diagnostics to Drug Discovery

Tuberculosis (TB) remains a global healthcare crisis, with an estimated 5.8 million new cases and 1.5 million deaths in 2020. TB is caused by infection with the major human pathogen Mycobacterium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods...

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Bibliographic Details
Published in:Microorganisms (Basel) 2021-11, Vol.9 (11), p.2330
Main Authors: Molloy, Antonia, Harrison, James, McGrath, John S., Owen, Zachary, Smith, Clive, Liu, Xin, Li, Xin, Cox, Jonathan A. G.
Format: Article
Language:English
Subjects:
Antibiotics
antimicrobial resistance
Bacteria
Cost analysis
COVID-19
diagnostics
Drug discovery
Drug resistance
Drug screening
Global health
Granulomas
Immune system
Infections
Microfluidics
Microorganisms
Mycobacterium
Physiology
Platforms
R&D
Reagents
Research & development
Research methodology
Research methods
Review
Reynolds number
Tuberculosis
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Summary:Tuberculosis (TB) remains a global healthcare crisis, with an estimated 5.8 million new cases and 1.5 million deaths in 2020. TB is caused by infection with the major human pathogen Mycobacterium tuberculosis, which is difficult to rapidly diagnose and treat. There is an urgent need for new methods of diagnosis, sufficient in vitro models that capably mimic all physiological conditions of the infection, and high-throughput drug screening platforms. Microfluidic-based techniques provide single-cell analysis which reduces experimental time and the cost of reagents, and have been extremely useful for gaining insight into monitoring microorganisms. This review outlines the field of microfluidics and discusses the use of this novel technique so far in M. tuberculosis diagnostics, research methods, and drug discovery platforms. The practices of microfluidics have promising future applications for diagnosing and treating TB.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms9112330