Efficacy of micronutrient supplementation on skin aging and seasonal variation: a randomized, placebo-controlled, double-blind study

Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative sk...

Full description

Saved in:
Bibliographic Details
Published in:Clinical interventions in aging 2013-01, Vol.8, p.1527-1537
Main Authors: Fanian, Ferial, Mac-Mary, Sophie, Jeudy, Adeline, Lihoreau, Thomas, Messikh, Rafat, Ortonne, Jean-Paul, Sainthillier, Jean-Marie, Elkhyat, Ahmed, Guichard, Alexandre, Kenari, Kamran Hejazi, Humbert, Philippe
Format: Article
Language:English
Subjects:
Adult
Aging
Confidence Intervals
Dietary Supplements
Double-Blind Method
Double-blind studies
elasticity
Female
Health aspects
high frequency ultrasound
Humans
Medical research
Medicine, Experimental
Micronutrients - pharmacology
Middle Aged
nutraceuticals
oral supplementation
Original Research
relief
Reviscometer
seasonal variation
Seasons
Self evaluation
Skin
Skin - diagnostic imaging
Skin Aging - drug effects
Skin Aging - physiology
skin elasticity
skin relief
Treatment Outcome
Ultrasonic imaging
Ultrasonography
Visioscan
Weather
winter variation
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies have confirmed dramatic changes in skin surface parameters during the winter months. Although there are many studies supporting the positive effects of topical treatment, there are no published studies demonstrating the effects of oral supplementation in the prevention of negative skin changes during winter. The purpose of this study was to evaluate the efficacy of an oral micronutrient supplement in preventing the negative effects of winter weather on skin quality using noninvasive biometrologic instruments. This study included 80 healthy female volunteers aged 35-55 years with phototype II-IV skin. Randomization was balanced. Two tablets of a micronutrient supplement (Perfectil® Platinum) or placebo were administered once daily for 4 months. The volunteers were examined at baseline, after 4 months, and 6 weeks after termination of treatment (month 5.5). The evaluation included skin microrelief by Visioscan® as the main outcome, and the secondary outcomes were results on standard macrophotography, skin tension by Reviscometer®, skin high-frequency ultrasound, and self-assessment. For all pseudoroughness and microrelief indicators, there was a significant increase from baseline to month 4 in the placebo group (P
ISSN:1178-1998
1176-9092
1178-1998
DOI:10.2147/CIA.S43976