Involvement of autophagy in coronavirus replication

Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in...

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Bibliographic Details
Published in:Viruses 2012-11, Vol.4 (12), p.3440-3451
Main Authors: Maier, Helena J, Britton, Paul
Format: Article
Language:English
Subjects:
Animals
Autophagy
Cell Membrane - metabolism
Cell Membrane - virology
coronavirus
Coronavirus - physiology
double membrane vesicles
Humans
IBV
replication-transcription complexes
Review
Virus Replication
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Summary:Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3) in coronavirus replication.
ISSN:1999-4915
1999-4915
DOI:10.3390/v4123440