Extracellular Vesicles: An Emerging Regenerative Treatment for Oral Disease

Extracellular Vesicles (EVs) are small lipid-enclosed particles containing biological molecules such as RNA and proteins that have emerged as vital modulators of intercellular communication. Increasingly, studies have shown that EVs play an essential role in the occurrence and prognosis of oral dise...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2021-05, Vol.9, p.669011-669011
Main Authors: He, Fanzhen, Li, Lu, Fan, Ruyi, Wang, Xiaoqian, Chen, Xu, Xu, Yan
Format: Article
Language:English
Subjects:
bone
cartilage
Cell and Developmental Biology
dental pulp
extracellular vesicles
oral tissue regeneration
periodontal tissue
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Summary:Extracellular Vesicles (EVs) are small lipid-enclosed particles containing biological molecules such as RNA and proteins that have emerged as vital modulators of intercellular communication. Increasingly, studies have shown that EVs play an essential role in the occurrence and prognosis of oral diseases. EVs are increasingly considered a research hotspot of oral diseases. In addition, the characteristics of carrying active molecules have also been studied in oral tissue regeneration. Evidence has shown that EVs regulate the homeostasis of the inflammatory microenvironment, promote angiogenesis, and repair damaged tissues. In this review, we summarized the characteristics of EVs and highlighted the role of EVs in oral tissue regeneration, including dental pulp, periodontal tissue, cartilage, and bone. We also discussed their deficiencies and prospects as a potential therapeutic role in the regeneration treatment of oral disease.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2021.669011