5-Methylcytosine RNA Methyltransferases-Related Long Non-coding RNA to Develop and Validate Biochemical Recurrence Signature in Prostate Cancer

The effects of 5-methylcytosine in RNA (m5C) in various human cancers have been increasingly studied recently; however, the m5C regulator signature in prostate cancer (PCa) has not been well established yet. In this study, we identified and characterized a series of m5C-related long non-coding RNAs...

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Bibliographic Details
Published in:Frontiers in molecular biosciences 2021-12, Vol.8, p.775304-775304
Main Authors: Wang, Ke, Zhong, Weibo, Long, Zining, Guo, Yufei, Zhong, Chuanfan, Yang, Taowei, Wang, Shuo, Lai, Houhua, Lu, Jianming, Zheng, Pengxiang, Mao, Xiangming
Format: Article
Language:English
Subjects:
5-methylcytosine in RNA (m5C)
biochemical recurrence
lncRNA
Molecular Biosciences
prognostic model
prostate cancer
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Summary:The effects of 5-methylcytosine in RNA (m5C) in various human cancers have been increasingly studied recently; however, the m5C regulator signature in prostate cancer (PCa) has not been well established yet. In this study, we identified and characterized a series of m5C-related long non-coding RNAs (lncRNAs) in PCa. Univariate Cox regression analysis and least absolute shrinkage and selector operation (LASSO) regression analysis were implemented to construct a m5C-related lncRNA prognostic signature. Consequently, a prognostic m5C-lnc model was established, including 17 lncRNAs: , , , , , , , , , , , , , , , , and . The high m5C-lnc score calculated by the model significantly relates to poor biochemical recurrence (BCR)-free survival (  
ISSN:2296-889X
2296-889X
DOI:10.3389/fmolb.2021.775304